Synthesis, Characterization, and Antioxidant Activities of N-(Diphenylmethyene) hydrazine carbothiohydrazide a new Schiff Bases Derived from Substituted benzophenones and their Complexes

Abstract

Introduction

Metals have been used medicinally since ancient times, with silver as a disinfectant and gold for treating diseases dating back thousands of years. In modern times, gold complexes like Auranofin have been approved for rheumatoid arthritis and are being tested as anticancer agents. Other metals such as bismuth, antimony, mercury, and arsenic have also been used for bacterial, parasitic infections, and cancer treatment. The discovery of cisplatin’s anticancer properties in 1965 revolutionized metal-based chemotherapy, leading to platinum drugs widely used in cancer treatment today.

Metal complexes offer versatility by tuning metal oxidation states and ligands to optimize medicinal effects. Among ligands, thiosemicarbazones (TSCs) are well-studied for their metal-chelating ability and biological activity. Thiocarbohydrazones (TCHs), related compounds first synthesized in 1925, have gained recent interest.

The text focuses on the synthesis and characterization of complexes formed between N-(diphenylmethylene)hydrazine carbothiohydrazide (DTCH) and metals like Co(II) and Ni(II). DTCH coordinates mainly through thiol sulfur and hydrazine nitrogen atoms, forming stable complexes with octahedral geometry. These complexes are mostly insoluble in water but soluble in organic solvents, are non-ionic, and show magnetic properties consistent with their metal centers. IR spectroscopy confirms coordination sites and ligand behavior, while thermal studies show stability and water coordination. Electronic spectra indicate charge transfer transitions with no clear d–d bands in solution.

Conclusion

Thus on basis of electric conductance, magnetic susceptibility and I.R. spectral studies the following structures are tantively suggested for the complexes M(DTCH)2.nH2O

References

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Copyright © 2025 Dr. Sanjay Kumar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.